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Vitamin D and Gut Bacteria: More Clues and Questions

Blog Summary

I just got back from ACTRIMS (Americas Committee for the Treatment and Research in MS), where more than 700 MS doctors and researchers shared their results, especially their work aligned with this year’s theme: Environmental Factors, Genetics, and Epigenetics in MS Susceptibility and Clinical Course. This was my first time at ACTRIMS and I found the theme and the talks really compelling.
 
One thing that struck me is the evolving story about how specific things we all encounter in our lives interact with the “cards” (genes) we were dealt at birth. Our genes predispose us to be susceptible to various medical conditions, but that doesn’t mean we will get those conditions. In the case of MS, now there are 200 genetic variants identified that increase a person’s likelihood of getting the disease. I’m struck by how many “moving parts” seem to be involved in whether or not a person gets MS and what their MS experience and course will be...

From ECTRIMS: New Results on Gut Bacteria and MS

Blog Summary

The ECTRIMS meeting has been a great place to connect with researchers on what’s truly exciting in MS research. I’ve especially enjoyed hearing about an area of investigation that is moving forward quickly – from initial observations toward treatments or solutions for people with MS. From what I've heard this week, researchers who are looking at the gut microbiome and its role in the MS immune attack are doing just that.    Drs. Yan Wang, Lloyd Kasper and colleagues from Dartmouth Medical School and Eastern Washington University built on previous work, which had shown that modulating gut bacteria during MS-like disease in mice induced specific immune cells (called Bregs – or regulatory B cells), and these Bregs reduced disease severity...