Rapid Progress in Research on Cell-Based Therapies – Including Trial Results from Cleveland Clinic

Cell-based therapies that have the potential to both stop MS in its tracks and restore lost function are getting a lot of attention at this week’s ACTRIMS-ECTRIMS meeting. Stem cells can be found in different tissues and organs and under the right circumstances, can transform into specific types of cells when needed to repair injuries. These stem cells represent a promising area of research for both slowing MS activity and for repairing the brain’s myelin that has been damaged by MS.

But – Which cells? Given how? To whom? How often? – are some of the big questions that need to be answered with ongoing research. And while this approach has much promise, it is still experimental and not yet proven to work. Read more about different approaches to research into stem cells for MS.

One approach is to use these cells to replace the cells that make myelin – the protective cover on nerve wires which is damaged during MS – and nerve cells that have been destroyed.

Finding ample and uncontroversial sources of stem cells would help this effort. One exciting avenue being explored is to take samples of a person’s skin or other adult cells and reprogram them to become stem cells. These cells are called “induced pluripotent stem cells” or iPSC. Dr. Giulia Mallucci of the United Kingdom and Italy described a new process that could speed up research on this approach. The current approach involves reprogramming the skin cells via many steps and months to take them backward to become unspecialized stem cells, then reprogramming them again to force them to become specialized brain stem cells. In the new approach tested by this team, they turned mouse skin cells directly into specialized brain cells in one step.

The team had success with this new technique treating mice that had MS-like disease. (Read the abstract.) Other scientists are also pursuing this exciting area of research, including a group from Stanford University that will begin a Society-sponsored study in October examining the ability of human iPSC cells to repair the nervous system.

Until recently, scientist thought the transplanted stem cells migrated to the nervous system and directly replaced the lost myelin. But Dr. Stefano Pluchino of the U.K. presented data this week showing that instead, the transplanted cells actually provided signals that stimulated natural repair of other cells. As research continues to translate and understand these signals, it will open up the future possibility of creating medicines based on the signals without having to actually transplant cells. 

It was great to hear the much-anticipated first results from a small, Phase 1 clinical trial at the Cleveland Clinic involving people with relapsing MS. This trial tested the ability of people’s own stem cells taken from their bone marrow, called mesenchymal stem cells, to inhibit immune mechanisms and to augment the body’s natural tissue repair processes after they were expanded and re-injected. An early trial like this can’t give a clear read about benefit, but they did report finding no serious safety concerns or any uptick in disease activity. They are still evaluating their results, but Dr. Cohen suggested that so far it’s a green light to the next step – designing a larger, controlled study of this approach. Read the conference abstract.)

Another approach using stem cells is called autologous hematopoietic (blood cell-producing) stem cell transplantation" – or (HSCT). This experimental procedure is being explored in attempts to “reboot” the immune system and hopefully stop MS attacks. (Read an interview with Dr. Richard Burt about his HSCT clinical trial.) Dr. Carmen Alcalá of Valencia, Spain, reported that in their hands, this procedure was more effective against disease activity in people with active relapsing MS, rather than secondary-progressive MS. (Read the conference abstract.)

This is just a small sample of more than 9,000 research presentations being made this week at this incredible meeting. Stay tuned for more updates! 

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Bruce

Bruce Bebo, PhD

Bruce Bebo, PhD, is Executive Vice President, Research at the National MS Society, and was previously a research immunologist focusing on the influence of sex hormones on MS. He is a driven and passionate Society volunteer, successful fundraiser and advocate, fueled in part by the fact that his mother had MS.

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    91 Comments

  • Joan Loomis   Sep 13, 2014 5:35 PM
    My 31 daughter has recently been diagnosed with ms I joined the website and listened to the dialogue about international conference and am so grateful about the new information you are posting,so much to learn.!
  • Mary Schack   Sep 14, 2014 3:40 PM
    Would really like to see this trial done on humans with progressive ms
  • Branko  Sep 15, 2014 3:47 PM
    Thank you for the article. I recently stumbled upon a slideshare that explains stem cell therapy for MS and how it can stop progression. Hope to see the procedure work... The material is promotional in its last slide, but very informative informative otherwise:
    http://www.slideshare.net/StemCellExperts/stem-cells-for-ms-revised-38000516
  • Barbara   Sep 16, 2014 4:53 AM
    How can I, which has had RR MS for 10 years, get involved in the active trials in progress with cell-based research?
  • robert lipps   Sep 16, 2014 11:22 AM
    Thanks for all you do.
  • Jeffrey   Sep 18, 2014 5:12 AM
    I would love to be part of a Trail but it seems that the 'Masses" cannot get involved. I've had MS for 19 years now, I'm still walking, talking, working full-time. I haven't had a "relapse" as they say in maybe 3-4 years. I want to be and am willing to be a stem-cell Guinea Pig....
  • Loretta Wehmeier   Sep 18, 2014 11:05 AM
    I would definitely like to try the stem cell transplant. I had relapsing remitting MS for 8 years and now have Secondary Progressive. All the MS therapies are for the Relapsing Remitting Form of MS. We should have Medications for the Progressive form of MS years ago,
  • Tina Godinez   Sep 18, 2014 2:12 PM
    I have had MS for over 30 years. The fist 15 or so being RR and a change to SP thereafter. Fortunately the progression has been very slow. Much trouble with balance and mobility but just make myself keep going. I never give us the thought that someday... Things will be better.
  • Din Puttlitz   Sep 20, 2014 5:15 PM
    I have had ms for 53 yrs.-I have a wonderful neurologist,he put me on Aubagio 2 yrs. ago and I have not had an exascerbation since.I praise the research and my health is the best it has been since I was 17 yrs, old

    I am a recent widow and cannot believe I went through so much stress and survived so well.
    Thank all of you researchers and doctors for helping us out!
  • Angel S   Sep 24, 2014 3:53 PM
    Having a baby on oct. 9th. Can the cord blood help at all?
  • Penny   Sep 30, 2014 9:50 AM
    Would love to see some Phase III Clinical trials in my area (Louisville KY) that would give me an opportunity to participate in stem cell therapy research. Sounds like it may offer some real promise.
  • Dewey Brown   Oct 13, 2014 8:34 PM
    Know there is need for African-Americans males to volunteer for clinical trials would be honored to be considered for stem cell research. Had Relapsing for about 20 yrs. Stabilized finally by Tecfidera, finding good results with Ampyra for walking and using the Ness300 that, without which I'd be in a wheelchair. Thanks for all the researcy
  • Richard Stickney   Oct 22, 2014 10:22 AM
    Eventually everyone gets something. My something is MS. The FDA limits me too 3 Lortabs a day. The pain in my legs never stops - I am not a drug abuser. I was a Kick boxer and a fitness nut. I guess it is what it is and you just have to deal with it. I am a retired Scientist. Everything in nature and in math, even Chaos has attractors. If there is something that repels Myelin then there is something that attracts it. Thanks. -Richard Stickney
  • Jeanne   Oct 22, 2014 10:38 AM
    The current research with the skin cells, can they be programed to be axons that have been "killed" and no longer exist in the brain?
  • Abderrahmane Chahidi   Oct 22, 2014 11:42 AM
    I appreciated this too
  • Zhangqi   Oct 22, 2014 6:45 PM
    We are very glad to hear this news, my sister was diagnosed MS, it has affected her actions, language, thinking, etc.This research can help her?
  • athena   Oct 22, 2014 11:02 PM
    Hallo!
    Since I stopped interferon (3 years ago) I try to feed with honey, royal jelly and pollen. It's the best way to treat sclerosis, and all what occures. I m interested to hear from you.
    Best regards!
  • Ann Marie   Oct 23, 2014 11:24 AM
    I have had MS for 13 years.... Thankfully it has not taken a toll on me and I am still working, walking, nothing has changed... BUT I do feel cognitively things are changing alittle and it is very scary!!! I would love for stem cells to be the answer for us all!!!! I can't wait to hear more about this and the reality of it..... How many years before we know?
  • Yolanda   Oct 23, 2014 11:29 AM
    I would love to know if this applies to Primary Progressive MS, which I've had for 12 years.
  • Rhonda Barker   Oct 23, 2014 11:52 AM
    Peer, would this Cell-Based therapy address nerve pain?
  • Ahmed   Oct 23, 2014 12:16 PM
    Hi ...iam Ahmed from Egypt my wife had ms from 6 years during this years we got 2 babies ...she didnot got any medicine because of their price ...iam so sorry for this .....actually iam interested in a drug called benzatropine ...which may have a potential to generate myalin .......thank you ...and forgive me for my boor english
  • Denise   Oct 23, 2014 12:26 PM
    How do they decide a good cell to use? How can they tell a cell from a bad cell when we still don't know exactly everything about MS 0r what causes it? But this is very exciting & i pray we continue to move forward & find more ways to control 0r better yet STOP MS progression.
  • Danielle   Oct 23, 2014 12:28 PM
    I would love it if PPMS and SPMS patients could be included in the trials/research.
  • j.c   Oct 23, 2014 12:35 PM
    I was diagnosed with relapsing/remitting 20 yrs. ago.
    I am anxious to hear more on this study!
  • Susan   Oct 23, 2014 1:15 PM
    I have MS, I cope with every symptom, as it affects my life everyday living. If the resources and studies help find a cure for this disease, I would be interested in hearing about it.
  • Ann Norman   Oct 23, 2014 1:51 PM
    Many thanks for the excellent article on the stem cell research situation and for flagging up these blogs.
    I have been waiting expectantly for several years for more positive stem cell research results to surface. That is, since hearing an exciting talk given to our local (WestOxon) MS group about some initial ground-breaking research (involving magical green mice!) in Oxford that preceded the later breaking stem cell news in the press.
    Stem cell research seemed then to be by far the most promising of all the MS research avenues I had read about. I still feel the same, but much more so now with so much positive news arriving daily.
    Most MSers will agree that the very long wait for any resulting effective treatments is very hard to bear.
  • sharon murtagh   Oct 23, 2014 2:32 PM
    I was diagnosed with ms at 26 but showed signs from age of 10 , now 4 members of my family to date also had and Have it , 3 cousins all first cousins on my dads side but my dads ,dad my grandfather also had it but he is watching over us all now ...Its amazing The reseach thats been done , Im longing for The day i get The choice about going back to full time work just to Have à chance to own my own home ....thank you so much for all The work ye are doing and will continue to do
  • Ross Caslick   Oct 23, 2014 2:40 PM
    Always appreciate being updated on the research for a cure . Amazed at the MS support out there. My neurologist Dr. John Kay seems optimistic that there are new discoveries
    pending
  • Kathryn   Oct 23, 2014 2:52 PM
    It's wonderful that there is hope on the horizon for RRMS but what about those of us with SPMS..there does't seem to be any treatment options..I am from New Zealand I had symptoms from 13 years of age,, diagnosed at 36 and put on beta interferon which I used for six years in which time my EDSS went form 2 to 6 .My neurologist says there is nothing he can offer me for my SPMS
  • Lauris   Oct 23, 2014 3:25 PM
    Yes, interested. Visible MS >25 years; now SPMS, use power wheelchair. On meds since 1st approved (1993). Switched due to side effects from Betaseron to Avonex to Copaxone. What's available and what trials involve SP?
  • Denise   Oct 23, 2014 3:44 PM
    Hi I was diagnosed RRMS nearly 6 yrs ago right out of the blue, aged 49. No clues I can think of to suggest how long it's been doing its worst. 18 months ago we were told I am now SPMS and boy has that been fast work. I am in a wheelchair full time, but I grit my teeth and I still work, with a huge amount of help from my hubby and my employer. We have a mortgage to pay-simple as that! My worry is that the stem cell thing is going too slow for me. I'd like to know, at what stage would a person have to be at before the stem cell 'thing' wouldn't work or be of benefit? I devour the research pages and stem cells seem to be the only treatment with any kind of promise. It seems to me to be the only thing that makes sense. I'd be happy to try any 'quacks' the way I feel at the moment! How long are we talking before something is available?
  • Sandra   Oct 23, 2014 4:11 PM
    My grandaughter is 16 and was diagnosed with MS over a year ago I have so much hope for the future each time I receive your emails. Thank you
  • connie   Oct 23, 2014 4:15 PM
    Once stem cell therapy is available, what will administration/therapy look like (i.e., surgical; IV therapy)?
  • dianne   Oct 23, 2014 6:27 PM
    I was diagnosed with MS on February 28,1993. That was the day I was finally told why I was walking and clearing everything off of the wall (pictures!) For the prior 3 months I was constantly told I had the flu and needed to re hydrate myself (I as dehydrated badly!) I was married and had 2 little girls ages 4 and 2. Stephanie, my oldest, was very helpful and did thing for me that she never should have had to do. (Prepare meals (as much as a 4 year old could do!!) I still can hear her tell her dad that her mom just laid around because she could not walk to the kitchen and do anything. Melisa was my youngest and she had what was diagnoses as delayed speech. She had her own language and I understood it very well. We would sit at the table talking to each other but nobody knew what we were saying! I went to Cleveland Clinic Melon Center to find out how I could finally get this cruel disease into remission. Ten years of constant Steroids being pumped into my body was NOT PLEASANT! I went through Betaseron therapy and for the most part that was not the answer! My Dr put me on Ampyra and that helped me tremendously! He then suggested Tysabri so on June 2010 I began using that! Finally I FEEL LIKE A NORMAL! (what ever that is) But I can drive a car, walk, run my home, pretty much what ever is asked of me I can do. I was told about 2 years ago that I was JC Positive but my Dr wants me to stay on this treatment while my risk of PML is low. Since then I have been checking into other therapy's I do not want to do the self injections but I am sure that there is something out there or in the works that is just for me to keep me as I am now! Since my diagnosis my husband has been told that he has severe nerve damage and a crushed spinal column. He is also a brittle diabetic and relies on me to drive him to his appointments for his Drs. He has been told now that he has Stage 4 renal failure and I am living with a of my issues. I thought he was going to be my care taker but as luck would have it I am his!

    Come on MAGIC CURE!! I need help!
  • Glenn   Oct 23, 2014 6:43 PM
    Keep up the "GREAT WORK" Ya can't get to much info.
  • Steve Johns   Oct 23, 2014 8:09 PM
    Drug regulation reform.

    Our system for treatment evaluation badly needs reassessment and reform. The system originated because of a need to protect people from snake oil salesmen but has been debased into a system for protecting vested monetary interests at the expense of the people it should be protecting.
    I have PPMS and have been involved in a phase 3 trial of Fingolimod for the last 3 years. As you know it was approved for other types of MS in about 2008 but, as PPMS had been kept out of the previous trials, not for Primary Progressive. This has of course only removed 10% of the ‘market’ (read people who need it) and has allowed Novartis to wait a few years then run these trials and then claim a ‘new application’ and so extend their patent by about 8 years allowing them to continue to charge $3000 for 28 day’s supply.
    This highlights 2 issues. Firstly the drug has been shown to slow the progression of the disease. There would not be a phase 3 trial at all if no effect had been observed. In PPMS the average progression from diagnosis to death is about 17 years and there are no other treatments for the progression of this disease so with holding this drug from this group for 8 years is a significant sentence for these people and a serious abuse of human rights.
    Secondly the use/abuse of the system to extend the life of their patent and so allow the company to sell the drug to 90% of their market for 8 years and then start the clock again on the patent for 100% of the market at a price that is determined by how much can be screwed out of government subsidies (they couldn’t sell it for this amount otherwise) is a serious rort and amounts to fraudulently obtaining tax payers money.

    This is technically not criminal because it is not illegal but it is certainly not ethical or morally justifiable. It has denied access to this drug for the people (yes PEOPLE, patients are people) who could have benefitted from this drug for 8 years, during which time many have suffered terribly, and all in the name of company profits and, possibly, jobs for people conducting the new round of unnecessary trials. This corruption, and it definitely is corruption, is the main reason why reform of the system is so badly needed.
    Another part of the system that needs reform is the trial process itself. The double blinded, placebo controlled trial is the gold standard for identifying and quantifying effects but is not necessary in many instances for approving drugs and only serves to make trials far more expensive than necessary. Such a trial is unarguably the most accurate but what is needed is the most appropriate method of assessment. This will be the type of trial that gives the most relevant information to what the trial is assessing. If a drug has been shown to be safe and to have an effect in phase 1 and 2 trials and to, for example, slow the progression of a disease by approximately 70%, then a phase 3 trial should be unnecessary or could be simplified, speeded up and made more effective. The placebo control group could be eliminated entirely because there will always be a placebo effect in some people when the drug is available on prescription and the control is the entire medical history of the disease to date. This is not as close to an exact comparison as with a placebo control group but even such a control group is not an exact comparison. In this instance though this would be irrelevant because the placebo effect will not be 20% and the difference between ‘approximately 70%’ and ’67.32 percent makes no difference to anything. You could treble the size of the trial and perhaps calculate the results out to 67,3897348% and this would be far more accurate but gives no additional useful information.
    In this instance then if all participants in the trial were given the active drug, as opposed to half receiving a placebo, then the size of the trial is doubled and this in itself tends to even out the effects of any aberrant individual reaction.
    It is also far more ethical to give all participants the active drug than to deceive half the participants to observe their decline and suffering to be able to get a more accurate assessment of the last decimal place for the percentage effect. In fact when you know that the effectiveness is, say, 70% then the use of a placebo this way is immoral.
  • nelly farid   Oct 23, 2014 8:18 PM
    Very important researches.thx alot & i need more
  • Lorna   Oct 23, 2014 10:25 PM
    I have been diagnosed with m.s for 22 years. Initially r/r now secondary progressive. I am interested in all the research, but I would like to know who will be the pts to receive any ground breaking treatment, as I have lived in many areas in England and received such varied treatment and care. I understand the frustrations from health professionals at times, and the balance to concentrate on palliative care, and I have kept myself as well as possible, as I bring up my 2 children. However, I have felt brushed under the carpet at times...when I have needed help...making me quite despondent. I am looking to move now...do I look to find an area that is positive towards helping pts. with m.s? should it not be universal? thank you. I don`t want to moan, I need to know for my future .
  • Eleni   Oct 23, 2014 10:53 PM
    I hope for a soonest treatment ,because I've lost by better friend from ms five years ago
  • interesting!!!   Oct 23, 2014 11:08 PM
    interesting!!!
  • interesting!!!   Oct 23, 2014 11:08 PM
    interesting!!!
  • Jurii   Oct 24, 2014 12:44 AM
    Очень интересно! Обнадёживает!
  • Joan Jordan   Oct 24, 2014 2:14 AM
    Excited about this- maybe it's the missing link!!!
  • RADHIKA   Oct 24, 2014 2:25 AM
    I am suffering from MS since 10 years ,and had attacks three times . this article is great , but how fast this will start working on MS Community is a challenge . We are based in India and have Ms society , it will be great if you can be linked up with that and this research can help various doctors of INDIA with their trials .
  • Pezhman   Oct 24, 2014 2:39 AM
    As I suffer Devic and my identical twin brother suffers MS!!! ,
    I prefer to hear about the relationship between these two diseases.It must be a wonderful case for researchers around the world but no one has taken it serious in my country!!! This rare case may help scientists to understand about the pathogenesis and maybe the treatment of Devic and MS.
  • Van Neste   Oct 24, 2014 3:14 AM
    Thank you very much for this information. My 40 year old daughter has progressive MS. Therefor, I really hope that very soon clinical testing on humans will be performed. Please keep us updated.
  • Jacqueline Peabody   Oct 24, 2014 3:15 AM
    I was diagnosed with PPMS in 1998 and was in a scooter within a year. I was involved in the only ever drug trial for progressives, the Promise Trial. It's almost a joke when I receive any MS literature because I know it doesn't include me. MS can make you feel like a second class citizen, but do we have to receive the same treatment from the MS world also?
  • Ali   Oct 24, 2014 3:37 AM
    The information is good, thank you for sharing this. All the comments and opinions are worth reading too. I have MS, 10 years ago I suddenly found myself in hospital and thought I had a stroke, no, after lots of tests and needles, I was told I had MS. This happened just before my 40th birthday, so it was not a happy year! I still work full-time, walk, I have to be determined and am often astounded at how people treat me when they hear I have MS. I am currently doing my doctorate, my focus is my experience of MS and all the issues I have faced and others.
    I am so pleased to hear that there is so much research happening. Let us all push for treatments to finally be accessible .
  • Graham Cooper from Australia   Oct 24, 2014 4:21 AM
    Having been diagnosed with MS 2001 now in 2010 my most recent MIR I now I have PPMS I have tried all medication to help slow down my MS but none work. My neurologist told me recently on our last meeting ( 23/10/14) that there is nothing available for me.He is going to put my name forward to a trail when there is one he dose not know when that will be, so if possible can I please be in nyour trail
  • Graham Cooper from Australia   Oct 24, 2014 4:21 AM
    Having been diagnosed with MS 2001 now in 2010 my most recent MIR I now I have PPMS I have tried all medication to help slow down my MS but none work. My neurologist told me recently on our last meeting ( 23/10/14) that there is nothing available for me.He is going to put my name forward to a trail when there is one he dose not know when that will be, so if possible can I please be in nyour trail
  • Delio Monti   Oct 24, 2014 4:23 AM
    E' dal 1985 che ho MS in forma primaria, la sedia a rotelle si avvicina, vi ringrazio nel tenermi informato, la lotta continua... con tutti voi che credete in una svolta vicina ed un sorriso verso il futuro...
  • Delio Monti   Oct 24, 2014 4:23 AM
    E' dal 1985 che ho MS in forma primaria, la sedia a rotelle si avvicina, vi ringrazio nel tenermi informato, la lotta continua... con tutti voi che credete in una svolta vicina ed un sorriso verso il futuro...
  • John Desport   Oct 24, 2014 5:14 AM
    Hi,I was diagnosed some thirty-one years past ( I am now sixty y.o.) , I have seen many hopefull treatments come and go ( although these have been for 'remitting relapsing never c.progressive ) .
    No treatment seems to address the issue of why,or how to prevent, the destruction of the nerve sheaths ? Surely until this is resolved new sheath repair is academic ?
    Thanks
    John
  • Anne, Belgium   Oct 24, 2014 5:27 AM
    Sorry, but I am French speaking and it's too dificult to follow you. I wish you a lot af succes, but I want to unsubscrite.
    Have fun,
    Anne
  • Дима   Oct 24, 2014 5:54 AM
    Да! Рс очень сложное заболевание
  • Olympia Hadjimichael   Oct 24, 2014 7:49 AM
    My daughter was diagnosed at the age of 21 and has MS for 24 years. She is now SP, is considered legally blind, and has serious memory and executive function difficulties. She is very eager to try stem cell therapy to improve her quality of life.
  • Gerry Cloete   Oct 24, 2014 8:41 AM
    Thank you for your email and hope to hear again from you.
  • polyraz  Oct 24, 2014 9:16 AM
    Hello to all M.S. Organizations, Doctors, Researchers etc.
    Thank you for all of your devotion to this maladie and the people affected by it.
    I am, with my wife and children, personally affected with Primary Progressive MS. I've been diagnosed since almost 9 years but have had symptoms for the last 30 odd years. I've been to many MS presentations with many Doctors and researchers and for the first time this year attended a conference that actually focused on PPMS. I and many others like me realize that we are in the 10% minority of MS'ers but we should still count.
    Please help our group of PPMS 'ers with additional funding and research dollars as our time is very limited. The forms of progressive MS are not more important than the other types but our light is fading quickly. There is a frustration among this group of MS'ers and I feel the need to speak again in representation for all of us. Please hear our cry and understand that all MS'ers are in need of hope as that is the only thing that drives us to wake up every day and continue our battle. We share that hope with our families and friends. Stem cell research seems to be the most viable solution to our dilemma and so many of us want to participate in the protocols.Thank you for understanding our view and please try to expand the stem cell protocols to involve more of us for a quicker cure.
    Sincerely,
    Danielkki
  • Jane Rodocker   Oct 24, 2014 10:00 AM
    I have had MS for 30years. I am 63 now. I think stem cell is
    My only hope..I am bed riden, I can't even roll on my side, or
    use the bathroom. I have no use of my left arm & I can't open
    my hand. PLEASE HELP !!!!!!
  • Jane Rodocker   Oct 24, 2014 10:00 AM
    I have had MS for 30years. I am 63 now. I think stem cell is
    My only hope..I am bed riden, I can't even roll on my side, or
    use the bathroom. I have no use of my left arm & I can't open
    my hand. PLEASE HELP !!!!!!
  • CheekyC   Oct 24, 2014 10:53 AM
    I was diagnosed 10 years ago and couldn't imagine then this would happen in my life tiem now it feel like it is just around the corner keep up all the positive research work !
  • M. Watson   Oct 24, 2014 12:40 PM
    My daughter has had progressive MS since 1997. There has been no medications for this type of MS and it is heartbreaking for patients that have no real treatment to watch some of the new medications being released - but never for them! We are so trying to keep hope alive!

    I cannot express how happy I am to receive your communication and certainly hope "improvement towards a cure" arrives soon. If she can be considered in the stem cell trial... we both welcome it. I say we because it affects me almost as much as her... because I am helplessly watching her go through this.

    Thanks for taking the time to reach out to us!
  • james   Oct 24, 2014 3:22 PM
    I too have secondary progressive MS. There is nothing there. If they have something it maybe too late ...RESIDUAL damage.
  • Bill Gibson   Oct 24, 2014 3:27 PM
    Would like to know how to join some clinical trials. I know that I only have a year or two left before I probably won't be able to walk. Wondering how long it could take to become available to the public? Please keep Me informed. Thank You
  • Jennifer   Oct 24, 2014 8:24 PM
    I am very much interested in stem cell research for those of us who have MS. Looking forward to more information on the subject.
  • Rena Steer   Oct 24, 2014 10:12 PM
    I was do in 1993 with MS. In 2007 I was misdiagnosed with Paratrigeminal Neuralgia. Then in 2008 I was diagnosed with Trigeminal Neuralgia. This disease is in the ranking of Ebola Virus and Typhoid as the most terrifying diseases. This horrible disease that is often related to MS needs to be brought to light as much if not more than MS which has many fund raising initiatives. Trigeminal Neuralgia (aka suicide disease) has its grip in so many and so many need help! Please help.
  • João   Oct 25, 2014 3:40 AM
    Does someone know what MS really is?
    Is it the immune system attacking the myelin?
    Or is it something else causing destroying the myelin and prompting the immune system to act (and make it worst)?
    I fear that these recent therapies may be giving us false hopes.
    Lets wait for the human trials, I think these will be a surprise, and may reveal something more about MS.
    Regarding MS I feel doctors and researchers are in the middle age, taking care of black plague patients, and only protected by a mask full of spices.
  • patience lowe   Oct 25, 2014 5:40 AM
    sister twin both ms
    differences in course
    diet related
    no aspartame me
    no sugar me
    copaxone me and her
    no wheat me
    no dairy me
    me work full time in sales
    her completely disabled
    me high lesion load
    her too many drugs and not compliant with copaxone
    me cognitine,vitamin c,d,e,b100, bee pollen , propalis, royal jelly, spirulina, probiotics,
    ampyra me
    sometimes baclofen
    and turmeric with curcumin three times a day, off all anti-inflammatories and had had three gi bleeds. very sick
    also take cod liver oil pills.
    fatigue mild don't walk long distance over weight
    would like to start a n injection slows emptying belly and another helps liver with sugar.
    otherwise marginally disabled after 10 years out of work
    had knee replaced 3 years ago
    shoulder surger 6 years ago
    think ms came on for both of us me lost daughter she victim of violent crime
    also significant both married very abusive men, early abandonment issues in child hood. both had 4 kids. live in new England.
    want to help? she is much more disabled, although both walking find, just slow, ampyra helps me a lot.
  • Judy Bayliss   Oct 25, 2014 11:19 PM
    msif had an exchange forum it has now ceased I found it excellent 4 cutting thru the bullshit & making me aware of how privil if if if if if if eged we r in if if if if if ifAustralia. I am 65 had 2 diagnose myself some 43 if years ago but may have had it all my life. If if ifAm I 2 old 2 benefit am in a wheelchair if if if ifbut strong fit do weights 3 if if if if if times a week plumbing poor so is speech mind but well read in the subject? TFzold 2 far gone & stemcells if if if if if a long shot if if if if. computer playing up hope u can c an a if if if if if if if ifvenue of research 4 advanced cases tho not if if if if if if if if if if bedridden crawl around live alone so if if if if if if if if me care
    thanx
    j b
  • Judy Bayliss   Oct 25, 2014 11:19 PM
    msif had an exchange forum it has now ceased I found it excellent 4 cutting thru the bullshit & making me aware of how privil if if if if if if eged we r in if if if if if ifAustralia. I am 65 had 2 diagnose myself some 43 if years ago but may have had it all my life. If if ifAm I 2 old 2 benefit am in a wheelchair if if if ifbut strong fit do weights 3 if if if if if times a week plumbing poor so is speech mind but well read in the subject? TFzold 2 far gone & stemcells if if if if if a long shot if if if if. computer playing up hope u can c an a if if if if if if if ifvenue of research 4 advanced cases tho not if if if if if if if if if if bedridden crawl around live alone so if if if if if if if if me care
    thanx
    j b
  • Jane   Oct 26, 2014 1:15 PM
    I would love to know more about MS. What are its triggers, what are the stages, what are the symptoms, how do one differentiate it from other neurological diseases. Does it affect ones ability to breathe effortlessly?
  • fatemeh mousavi   Oct 26, 2014 2:16 PM
    I like to research about MS
  • fatemeh mousavi   Oct 26, 2014 2:16 PM
    I like to research about MS
  • fatemeh mousavi   Oct 26, 2014 2:16 PM
    I like to research about MS
  • Suebarber   Oct 26, 2014 6:41 PM
    I would like research in repairing myelin.
    Oral medications.
  • tony mcgrath   Oct 27, 2014 4:48 AM
    I HAVE PROGRESSIVE MS AND I WOULD LOVE TO BE KEPT INFORMED OF ANY PROGRESS THAT IS BEING MADE TO HELP MY CONDITION.KEEP UP THE GREAT WORK AND HOPEFULLY A CURE CAN BE FOUND.
  • Ursula Dedeoglu   Oct 27, 2014 5:02 AM
    I have had MS for about 40 years. The first 35 or so being RR and a change to SP afterwards. Therefore I am interested very much in Medications for the Progressive form of MS !!!
  • RENUKAPOOR   Oct 27, 2014 5:52 AM
    i would like research in repairing myelin
  • RENUKAPOOR   Oct 27, 2014 5:52 AM
    i would like research in repairing myelin
  • PeterAdams   Oct 27, 2014 5:58 AM
    Diagnosed in 1978 at age 38. Classified as 'benign' but that term appears to have been discredited, presumably with experience of what happens in later life, so I am now 'RR'. No significant problems till last year but now stamina is such as to make walking painfull after half an hour and recovery takes a day after an hour's walk - symptoms which of course are trivial compared with which some sufferers have to cope. Trying to keep up gym attendance but is difficult. Fear for further progression of the symptoms and would like to beleve a treatment might be available soon. However existing trial lengths seem to make this unlikely.
  • Jacqueline   Oct 27, 2014 7:50 PM
    Hi I wonder if this applies to primary progressive I was diagnosed eight years ago , plus I live in Latin America , I speak Spanish only and is not well to do.
    Thank you very much .
  • Bonette Richards   Oct 30, 2014 1:07 PM
    Hi, I am interested in receiving updates on all research covering disease origin and symptomatic improvement.
  • Madeleine Cutting   Oct 30, 2014 3:16 PM
    When I opened the part about exercise, I was astonished to see a person lifting weights as I was under the impression that weights would lead to more spasticity. Also, on the same lines, you could inform on the "natural" medicines which improve symptoms of MS (as does exercise), but that would be detrimental to the Phamaceutical Industries who give financial support to our NGO'S!!!
    On the whole, I think it a wonderful idea.
  • Carolyn   Oct 31, 2014 12:52 PM
    I have secondary progressive MS. Any research which will lead to a treatment to halt this disease would be fantastic. Please keep trying.
  • Yvonne   Nov 1, 2014 1:42 PM
    Please help us!!!!! I know I speak for all PPMSers - we will try anything!
  • Wendy Currie   Nov 3, 2014 12:22 AM
    What chances are there of Relapsing and Remitting MS patients reverting to Progressive MS.
  • Garry D, Sefcovic   Nov 3, 2014 7:24 AM
    I have had rrms for 26 years with the last 41/2 being the worst with pain. My father had progressive ms at 28 and ending up in a vets hosital for 11 years
    He died at the age of 40. I see a lot of positive articles on stem cell research and seem to see some hope in it,Iam currently on Gilenya and still working
  • Susan. McDonald   Nov 9, 2014 8:43 PM
    Yes MS is a pain. In many ways.
  • saem ghazizadeh   Nov 21, 2014 10:07 AM
    Hi doctor
    My wife of 10 years, Mrs. Mary dad from a patient unfortunately ms .nv progressive disease and the patient's legs to move difficulty controlling urinary tract.
    Please send your tips or reception of data to the control treatment, we refer you to the clinic.
    Thanks a lot
  • Avatar
    Superman  Dec 1, 2014 12:22 PM
    Sounds promising .If test subjects are needed I would volunteer to test their theories . Can be contacted at email jeffshirley2014@gmail.com. only been recently diagnosed with MS. May 2014…
  • Sydney Kraushaar   Dec 8, 2014 3:05 PM
    Things are looking up for me!
    LYB,
    Mom