In the spirit of other peoples post I am posting about my experience with Rituximab since I couldn't find much about it prior to switching.
I was on Gilenya for the last year, which worked fine as well. Didn't have any side effects that I could tell and no new brain lesions at 1 year. My neurologist left, so I switched neurologists, and she wanted to be more aggressive in my treatment (plus the rebound from rituximab is supposed be less terrible, which is a consideration in case I want to get pregnant in the next bit) so we opted to switch to Rituxin.
Came off my Gilenya about 4 weeks before my first infusion was scheduled to allow my lymphocytes to come up a bit. Had blood test 1 week prior to infusion to make sure that happened.
Just did my infusion yesterday. Had no side effects during the infusion, got done in about 4 hours from the start of the infusion. The benadryl made me crazy sleepy, still a little sleepy today. Have a bit of a headache, but nothing that some tylenol didn't help.
I am 32, have RRMS, was just diagnosed 1 year ago.
Hope this is informative for anyone!